The game will be available in the following three editions:
- Standard Edition – Priced at $69.99 on PlayStation 5 and Xbox Series, and $59.99 on PlayStation 4, Xbox One, Switch, and PC.
- Cross-Gen Digital Bundle – Priced at $79.99, and grants players access to the Standard Edition across previous- and new-gen within the same PlayStation and Xbox consoles.
- NBA 2K22 NBA 75th Anniversary Edition – Priced at $99.99 for PlayStation 5, Xbox Series, PlayStation 4, Xbox One, Switch, and PC.
Dual-gen access is included for both the Cross-Gen Digital Bundle and NBA 75th Anniversary Edition for PlayStation 5 and PlayStation 4, and Xbox Series and Xbox One, and provides a version of the game on each console generation within the same console family. The NBA 75th Anniversary Edition for Switch will only be available on digital format in the EMEA region.
Two-time NBA All-Star Luka Doncic is the cover athlete for the Standard Edition and Cross-Gen Digital Bundle, while Kareem Abdul-Jabbar, Dirk Nowitzki, and Kevin Durant feature on the cover of the NBA 75th Anniversary Edition. The latter features cover artwork painted by Atlanta-based artist Charly Palmer.
In North America, players can purchase a special version of the Standard Edition featuring six-time WNBA All Star and WNBA Champion Candace Parker on the cover and available exclusively through GameStop and EB Games, marking the first female cover athlete in the history of the franchise.
In Japan, players can also purchase a special version of the Standard Edition that features Washington Wizards player Rui Hachimura, the first Japanese player to be drafted in the first round in 2019 and first Japanese player to reach the NBA Playoffs.